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These measurements were made prior to and following a 10 -minute period of sitting or during a period of rest while lying down, with or without leg exercises, which were performed by extending the foot back and forth every two seconds for a third of the time spent lying down.Earlier work has demonstrated that prolonged sitting for up to 6 hours results in a decline in both blood flow to the limbs and in our larger arteries ability to widen to accommodate increased blood flow.Results showed that a 10 minute period of sitting reduced participants ability to rapidly increase blood flow to the lower legs via small blood vessels, but it did not affect the widening of larger arteries in response to increased blood flow. This is the first study to show that sitting for just 10 minutes is sufficient to reduce blood flow to the legs and impairs the function of small blood vessels supplying muscles in the leg."These findings further our understanding of the negative impact of inactivity on blood vessel function and demonstrate the positive effects of simple leg exercises whilst lying down providing further insight into how inactivity affects vascular health of the lower legs", says study author Dr Paul Fadel.The findings appeared in the journal Experimental Physiology. However, the researchers only tested healthy young males and their findings cannot be extended to females.Performing simple leg exercises can make a huge change and prevent such problems, a new study reveals.

The researchers aimed to find out whether these reductions were caused by sustained sitting, or whether 10 minutes would be sufficient to have a negative effect. However, this study suggests that we might be able to reverse this impairment to some extent by performing some simple leg exercises when lying down in bed or on the sofa. It remains unknown as to how these responses may vary with age, or with people who have heart problems.The study demonstrates changes in blood vessel function measured at the level of the knee.This paper also highlights a reduction in the function of small blood vessels when lying down.The effects of sitting on blood circulation have been attributed to blood passing more slowly through arteries while sitting..The researchers used a Doppler ultrasound technique alongside the knee to measure blood flow and examined the extent to which blood vessels widened in 18 healthy, young males.

The results also suggest leg exercises can help maintain rapid increases in the blood supply to the limbs. Studies designed to investigate the impact of repeated bouts of short-term sitting on blood vessel function are needed.Further study may investigate the impact of sitting and inactivity on blood vessels in other Infusion set Factory places in the body.Washington: Did you know how beneficial are simple leg exercises while lying down? A sedentary lifestyle can cause an impairment of transportation of blood in the body which in turn may increase the risk of diseases in the heart and blood vessels.

Mr Kothari said that recent circulars from NACO, permitting bulk transfer of blood bags from "blood excess" blood banks to "blood deficient" blood banks, transfer of plasma for fractionation, online updating of stocks on national portals could be the only ways to prevent rampant wastage. In the past two years, between January 2014 and December 2015, 22,394 litres of all components were discarded due to delay in uغير مجاز مي باشدe. "There has to be legislation or penal provision relating to blood wastage, and appropriate changes must be made in the age-old archaic Drugs and غير مجاز مي باشدmetics Rules, 1945. There has to be a regulatory body as well for the same," added Mr Kothari.Currently, there is no legislation or penal provision to keep tabs on the expired blood.Mr Kothari’s query regarding blood collection, uغير مجاز مي باشدe and wastage of blood units from January 2011 to December 2015 found lakhs of units of Freshly Frozen Plasma (FFP), Packated Red Blood Cells (PRCB), Liquid Plasma and Whole Blood (WB) being discarded due to prolonged storage of the same.. The figures, including statistics of all 63 blood banks in the city, confirmed that while a total 41,88,077 units (14,65,826 litre) of blood has been collected in the past five years, around 1,30,000 litres of this blood along with FFP and PRCB have expired owing to not being used on time.Responding to an RTI query filed by activist Chetan Kothari, Mumbai District AIDS Control Society has revealed shocking statistics of rampant wastage of blood taking place in 63 blood banks across the city. Also, mega camps, which jeopardise the safety of blood, must be discouraged," he said. FDA, which is Blood Collection Needle Suppliers one of the regulating bodies, is tasked with the job of keeping tabs on blood banks on whether they are following norms, discarding expired blood and so on. "Social workers have to be proactive and there has to be better coordination among them.

Next meeting of the Council will be on June 18, when it will take up lottery taxes and e-way bill.The Council also lowered GST rates on children&Infusion set assembly machine Suppliers39;s drawing books to nil from 12 per cent.Tax rate on kajal has been lowered to 18 per cent from 28 per cent.Movie tickets غير مجاز مي باشدting Rs 100 and below will now attract 18 per cent tax, as against 28 per cent proposed earlier, while those above Rs 100 will continue to attract 28 per cent GST.GST on insulin and agarbatti has also been lowered to 5 per cent, while school bags will attract tax of 18 per cent.The GST Council also decided that traders, manufacturers and restaurant owners with turnover of up to Rs 75 lakh can opt for a composition scheme and pay taxes at the rate of 1, 2, and 5 per cent respectively.Kitchen use items like pickles, mustard sauce and morabba will attract 12 per cent GST, as against 18 per cent proposed earlier.

On the issue of review of GST rate on hybrid cars, it was decided that the council will take it up after considering states' comments on a detailed paper issued on the matter earlier. New Delhi: Tax rates on certain kitchen items like pickles and mustard sauce, as well as movie tickets غير مجاز مي باشدting up to Rs 100 have been lowered as the Centre and states today reduced levies on 66 items."GST Council has reduced tax rates of 66 items as against representations received for 133 items," Finance Minister Arun Jaitley told reporters here after the 16th meeting of the GST Council. GST on insulin and agarbatti has also been lowered to 5 per cent, while school bags will attract tax of 18 per cent.

Louis. Laurie Tsilianidis, an endocrinologist at Cleveland Clinic Children’s in Ohio who wasn’t involved in the study.The findings are drawn from data on nearly 26,000 adults and children being treated for type 1 diabetes at 80 endocrinology practices in the U. Of those with other autoimmune disorders in addition to diabetes, 20 percent had one additional problem and 5 percent had at least two additional diseases, researchers report in the Journal of Clinical Endocrinology and Metabolism.Thyroid diseases were the most common autoimmune disorders, affecting about 24 percent of the participants. “The pattern that emerged was striking: autoimmune diseases begin early in childhood, where nearly 20 percent of those under age 6 already have additional diseases other than type 1 diabetes,” Hughes said by email.But the new study also held some surprises about how early and late in life these added health problems might surface, said lead author Dr.

Patients often develop other immune system diseases, too. Jing Hughes of Washington University School of Medicine in St.jpeg Infusion set Manufacturers In type 1 diabetes, the immune system attacks the pancreas and destroys its insulin-producing cells.In type 1 diabetes, the immune system attacks the pancreas and destroys its insulin-producing cells.“This is particularly true once they become adults, and Caucasian women carry the greatest risk,” Tsilianidis added by email.S.Even so, the findings suggest that people with type 1 diabetes should get routine screening for other autoimmune diseases – particularly celiac disease and thyroid disorders – the authors conclude. They also tended to have been diagnosed with type 1 diabetes at an older age, and to have lived with the condition for longer.People with type 1 diabetes often develop other autoimmune disorders, such as thyroid and gastrointestinal diseases, and a recent study yields new information about this link.“The take home mesغير مجاز مي باشدe is that kids with type 1 diabetes are at increased risk for developing other autoimmune diseases compared to kids who don't have type 1 diabetes,” said Dr. Celiac disease damages the small intestine and interferes with the absorption of nutrients if patients consume gluten, a protein in wheat, rye and barley; it can lead to complications like malnutrition, low bone density, lactose intolerance and infertility. AA Diabaties checking. One limitation of the study is that researchers lacked data on how old patients were when the autoimmune disorders developed, making it impossible to determine if participants gradually accumulated these diseases over time or if they were clustered around a certain age, the authors note.Participants with one or more additional autoimmune disorders were more likely to be older, female and white, the study found.Other diseases included Graves disease (overactive thyroid), rheumatoid arthritis and vitiligo. end-of. between 2010 and 2016. In most of these cases, the thyroid gland was underactive, which can lead to constipation, weakness, weight gain, depression and a slowed heart rate.“

Another surprise finding was that, while we had expected that autoimmune diseases may peak at a certain time of life, we found instead that the autoimmune burden continues to increase as patients age, to the extent that nearly 50 percent of those over age 65 have accumulated one or more additional autoimmune disease,” Hughes added.Type 1 diabetes often comes with other autoimmune diseases REUTERS Published: Oct 22, 2016, 2:09 pm IST Updated: Oct 22, 2016, 2:09 pm IST In type 1 diabetes, the immune system attacks the pancreas and destroys its insulin-producing cells.Celiac disease was the second most common autoimmune problem, affecting about 6 percent of participants. Indeed, in the current study, 27 percent of patients had at least one other autoimmune disorder.

While meat contributes valuable nutrients that are beneficial to health, including protein, iron, zinc, and vitamin B12, the current study indicates that meat should be eaten in moderation and the type of meat and its preparation method should be wisely chosen.The results showed that high consumption of red and processed meat is independently associated with NAFLD and insulin resistance regardless of saturated fat and cholesterol intake and other risk factors such as BMI.Low carb diets are frequently recommended to prevent metabolic diseases, researchers said.5 per cent. Low carb diets are frequently recommended to prevent metabolic diseases, researchers said.Individuals who consumed large quantities of meat cooked using unhealthy methods and those already diagnosed with NAFLD who consumed high heterocyclic amines (HCAs), which are pro-inflammatory compounds, had a higher chance of having insulin resistance.NAFLD was diagnosed in 38.High meat intake may up liver disease risk: study Low carb diets can be very rich in animal protein, especially meat.7 per cent of participants and insulin resistance in 30."Unhealthy Western lifestyle plays a major role in the development and progression of non-alcoholic fatty liver disease (NAFLD), namely, lack of physical activity and high consumption of fructose and saturated fat," said Shira Zelber-غير مجاز مي باشدi from the University of Haifa in Israel.After excluding some of the participants due to factors such as viral liver disease and alcohol abuse, nearly 800 subjects were included in the main analysis, of whom a sub-sample of 357 subjects completed the meat questionnaire."Our study looked at other common foods in the Western diet, namely red and processed meats, to determine whether they increase the risk for NAFLD," said Zelber-غير مجاز مي باشدi, who led the study published in the Journal of Hepatology. (Photo: Pixabay) Custom Safety injection needles Manufacturers High consumption of red and processed meat may increase the risk of developing non-alcoholic fatty liver disease and insulin resistance, a study has found.These low carb diets can be very rich in animal protein, especially meat.In order to test the association of type of meat and cooking method with NAFLD and insulin resistance, researchers undertook a study among individuals 40-70 years old who underwent screening colonoscopy

Most patients diagnosed with type 2 diabetes are treated with a "one-size-fits-all" protocol that is not tailored to each person custom infusion set  physiology and may leave many cases inadequately managed.The previous research attempted to define more subtypes of type 2 diabetes based on indicators such as beta-cell function, insulin resistance, or body-mass index, but those traits can vary greatly through life and during the course of the disease. "We need a more granular approach that addresses the many different molecular processes leading to high blood sugar.A new study by scientists at Harvard University indicated that inherited genetic changes may underlie the variability observed among patients in the clinic, with several pathophysiological processes potentially leading to high blood sugar and its resulting consequences.Researchers then applied for a "soft-clustering" approach known as Bayesian non-negative matrix factorization, which allows each variant to fall into more than one cluster."The clusters from our study seem to recapitulate what we observe in clinical practice," said Florez.Turns out, the study of all genes at the DNA, mRNA, and proteome levels, as well as the cellular or tissue level or simply the Genomic study can help cure type 2 diabetes. They found nearly a third of patients scored highly for only one predominant cluster, suggesting that their diabetes may be driven predominantly by a single biological mechanism. However, this failed to produce patterns that made biological sense. Inherited genetic differences are present at birth, and so a more reliable method would be to create subtypes based on DNA variations that have been associated with diabetes risk in large-scale genetic studies. The other three clusters contain DNA variants related to insulin resistance, including one cluster mediated by obesity, one defined by disrupted metabolism of fats in the liver, and one driven by defects in the distribution of fat within the body, known as lipodystrophy.When they next analysed measurements of diabetes-related traits from high-scoring subjects, they saw patterns that strongly reflected the suspected biological mechanism and distinguished them from all other patients with type 2 diabetes - for example, patients who fell into the obesity-mediated cluster were indeed found to have increased body-mass # index and body fat percentage."It is known that type 2 diabetes can be broadly grouped into cases driven either by the inability of pancreatic beta cells to make enough insulin, known as insulin deficiency, or by the inability of liver, muscle or fat tissues to use insulin properly, known as insulin resistance. These variations can be grouped into clusters based on how they impact diabetes-related traits; for example, genetic changes linked to high triglyceride levels are likely to work through the same biological processes.Related StoriesFitness, physical activity can lower risk of type 2 diabetesEating walnuts may halve type 2 diabetes risk: StudyAir pollution increases risk of type 2 diabetes, says study.The work performed as the first step towards using genetics to identify subtypes of type 2 diabetes, which could help physicians prescribe interventions aimed at the cause of the disease, rather than just the symptoms.To further test whether each cluster had been assigned the correct biological mechanism, the researchers gathered data from four independent cohorts of patients with type 2 diabetes and first calculated the patients' individual genetic risk scores for each cluster."When treating type 2 diabetes, we have a dozen or so medications we can use, but after you start someone on the standard algorithm, it's primarily trial and error," said senior author Jose Florez."The findings appeared in the Journal of PLOS Medicine. Two of these clusters contain variants that suggest beta cells aren't working properly, but that differ in their impacts on levels of the insulin precursor, proinsulin. For example, people who scored high on the lipodystrophy-like cluster were likely to be thinner than average but have insulin-resistant diabetes, similar to a rare type of diabetes in which fat accumulates in the liver, which is a fundamentally different process from insulin resistance that results from obesity. "Now we need to determine whether these clusters translate to differences in disease progression, complications, and response to treatment.Genomic study may help cure diabetes.The results appeared to reflect some of the diversity observed by endocrinologists in the clinic.The new work revealed five clusters of genetic variants distinguished by distinct underlying cellular processes, within the existing major divisions of insulin-resistant and insulin-deficient disease.To confirm these observations, the team analysed data for biology and disease research.Early efforts to do so using a "hard-clustering" approach, in which each genetic variation was assigned to only one cluster."The soft-clustering method is better for studying complex diseases, in which.Representational Image.By analysing genomic data with a computational tool that incorporates genetic complexity, the researchers identified five distinct groups of DNA sites that appear to drive distinct forms of the illness in unique ways. They found that the genes contained in the clusters were more active in the tissue types one would expect.The results appeared to reflect some of the diversity observed by endocrinologists in the clinic